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Means of 2 Samples with unknown Distribution
Entry Nr. 14, by user 1
Well known Test: "Wilcoxon Test" also known as "Mann-Whitney Test"

In R, you can perform the Wilcoxon Test this way:
R: wilcox.test(sample1,sample2)

More Info is here:
http://stat.ethz.ch/R-manual/R-patched/library/stats/html/wilcox.test.html